ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 410

Intramolecular
Cysteine 341 and cysteine 344
Cysteine 251 and cysteine 256
Cysteine 311 and cysteine 316
Cysteine 221 and cysteine 226
Cysteine 281 and cysteine 286
A redox-regulated disulphide may form within Zinc finger protein 410 between cysteines 341 and 344.

Details

Redox score ?
93
PDB code
6wmi
Structure name
znf410 zinc fingers 1-5 with 17 mer blunt dna oligonucleotide
Structure deposition date
2020-04-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
Q86VK4
Residue number A
341
Residue number B
344
Peptide name
Zinc finger protein 410

Ligandability

Cysteine 341 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 410 between cysteines 251 and 256.

Details

Redox score ?
90
PDB code
6wmi
Structure name
znf410 zinc fingers 1-5 with 17 mer blunt dna oligonucleotide
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide accession
Q86VK4
Residue number A
251
Residue number B
256
Peptide name
Zinc finger protein 410

Ligandability

Cysteine 251 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 256 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 410 between cysteines 311 and 316.

Details

Redox score ?
88
PDB code
6wmi
Structure name
znf410 zinc fingers 1-5 with 17 mer blunt dna oligonucleotide
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
6
% buried
0
Peptide accession
Q86VK4
Residue number A
311
Residue number B
316
Peptide name
Zinc finger protein 410

Ligandability

Cysteine 311 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 410 between cysteines 221 and 226.

Details

Redox score ?
88
PDB code
6wmi
Structure name
znf410 zinc fingers 1-5 with 17 mer blunt dna oligonucleotide
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q86VK4
Residue number A
221
Residue number B
226
Peptide name
Zinc finger protein 410

Ligandability

Cysteine 221 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 410 between cysteines 281 and 286.

Details

Redox score ?
88
PDB code
6wmi
Structure name
znf410 zinc fingers 1-5 with 17 mer blunt dna oligonucleotide
Structure deposition date
2020-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
7
% buried
10
Peptide accession
Q86VK4
Residue number A
281
Residue number B
286
Peptide name
Zinc finger protein 410

Ligandability

Cysteine 281 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of Zinc finger protein 410

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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