ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tax1-binding protein 1

Intramolecular
Cysteine 730 and cysteine 733
Cysteine 757 and cysteine 760
Cysteine 34 and cysteine 83
A redox-regulated disulphide may form within Tax1-binding protein 1 between cysteines 730 and 733 (10 and 13 respectively in this structure).

Details

Redox score ?
84
PDB code
4bmj
Structure name
structure of the ubz1and2 tandem of the ubiquitin-binding adaptor protein tax1bp1
Structure deposition date
2013-05-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
40
Peptide accession
Q86VP1
Residue number A
730
Residue number B
733
Peptide name
Tax1-binding protein 1

Ligandability

Cysteine 730 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 733 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tax1-binding protein 1 between cysteines 757 and 760 (37 and 40 respectively in this structure).

Details

Redox score ?
77
PDB code
4bmj
Structure name
structure of the ubz1and2 tandem of the ubiquitin-binding adaptor protein tax1bp1
Structure deposition date
2013-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
36
Peptide accession
Q86VP1
Residue number A
757
Residue number B
760
Peptide name
Tax1-binding protein 1

Ligandability

Cysteine 757 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 760 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tax1-binding protein 1 between cysteines 34 and 83. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4nlh
Structure name
skich domain of human tax1bp1
Structure deposition date
2013-11-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
72
Peptide accession
Q86VP1
Residue number A
34
Residue number B
83
Peptide name
Tax1-binding protein 1

Ligandability

Cysteine 34 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Tax1-binding protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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