a tool for identifying drug-targetable redox-active disulphides

Thioredoxin reductase 3

Intramolecular

Cysteine 76 and cysteine 133

A redox-regulated disulphide may form within Thioredoxin reductase 3 between cysteines 76 and 133 (187 and 244 respectively in this structure).

Details

Redox score ?

60

PDB code

Structure name

crystal structure of glutaredoxin domain of human thioredoxin reductase 3

Structure deposition date

2009-04-29

Thiol separation (Å)

8

Half-sphere exposure sum ?

49

Minimum pK_a ?

8

% buried

13

Peptide accession

Residue number A

76

Residue number B

133

Peptide name

Thioredoxin reductase 3

Ligandability

Cysteine 76 of Thioredoxin reductase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Thioredoxin reductase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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