a tool for identifying drug-targetable redox-active disulphides

Rho guanine nucleotide exchange factor 25

Intramolecular

Cysteine 253 and cysteine 333

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 25 between cysteines 253 and 333.

Details

Redox score ?

66

PDB code

Structure name

crystal structure of p63rhogef complex with galpha-q and rhoa

Structure deposition date

2007-10-04

Thiol separation (Å)

4

Half-sphere exposure sum ?

87

Minimum pK_a ?

9

% buried

100

Peptide accession

Residue number A

253

Residue number B

333

Peptide name

Rho guanine nucleotide exchange factor 25

Ligandability

Cysteine 253 of Rho guanine nucleotide exchange factor 25

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Rho guanine nucleotide exchange factor 25

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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