ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Calcium-activated potassium channel subunit beta-4

Intramolecular
Cysteine 72 and cysteine 76
Cysteine 54 and cysteine 148
Cysteine 68 and cysteine 119
Cysteine 84 and cysteine 113
Cysteine 38 and cysteine 173
A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-4 between cysteines 72 and 76 (2072 and 2076 respectively in this structure).

Details

Redox score ?
88
PDB code
6v35
Structure name
cryo-em structure of ca2+-free hsslo1-beta4 channel complex
Structure deposition date
2019-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86W47
Residue number A
72
Residue number B
76
Peptide name
Calcium-activated potassium channel subunit beta-4

Ligandability

Cysteine 72 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-4 between cysteines 54 and 148 (2054 and 2148 respectively in this structure).

Details

Redox score ?
86
PDB code
6v22
Structure name
cryo-em structure of ca2+-bound hsslo1-beta4 channel complex
Structure deposition date
2019-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86W47
Residue number A
54
Residue number B
148
Peptide name
Calcium-activated potassium channel subunit beta-4

Ligandability

Cysteine 54 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-4 between cysteines 68 and 119 (2068 and 2119 respectively in this structure).

Details

Redox score ?
86
PDB code
6v22
Structure name
cryo-em structure of ca2+-bound hsslo1-beta4 channel complex
Structure deposition date
2019-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86W47
Residue number A
68
Residue number B
119
Peptide name
Calcium-activated potassium channel subunit beta-4

Ligandability

Cysteine 68 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-4 between cysteines 84 and 113 (2084 and 2113 respectively in this structure).

Details

Redox score ?
80
PDB code
6v22
Structure name
cryo-em structure of ca2+-bound hsslo1-beta4 channel complex
Structure deposition date
2019-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86W47
Residue number A
84
Residue number B
113
Peptide name
Calcium-activated potassium channel subunit beta-4

Ligandability

Cysteine 84 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Calcium-activated potassium channel subunit beta-4 between cysteines 38 and 173 (2038 and 2173 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6v22
Structure name
cryo-em structure of ca2+-bound hsslo1-beta4 channel complex
Structure deposition date
2019-11-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
82
Peptide accession
Q86W47
Residue number A
38
Residue number B
173
Peptide name
Calcium-activated potassium channel subunit beta-4

Ligandability

Cysteine 38 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Calcium-activated potassium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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