ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

RNA N6-adenosine-methyltransferase METTL16

Intramolecular
Cysteine 183 and cysteine 247
Cysteine 518 and cysteine 548
Cysteine 181 and cysteine 183
Cysteine 181 and cysteine 247
A redox-regulated disulphide may form within RNA N6-adenosine-methyltransferase METTL16 between cysteines 183 and 247.

Details

Redox score ?
61
PDB code
6gt5
Structure name
mettl16 mtase domain (crystal form 2)
Structure deposition date
2018-06-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
100
Peptide accession
Q86W50
Residue number A
183
Residue number B
247
Peptide name
RNA N6-adenosine-methyltransferase METTL16

Ligandability

Cysteine 183 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA N6-adenosine-methyltransferase METTL16 between cysteines 518 and 548. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6m1u
Structure name
crystal structure of the vertebrate conserved region (vcr) of human mettl16
Structure deposition date
2020-02-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
54
Peptide accession
Q86W50
Residue number A
518
Residue number B
548
Peptide name
RNA N6-adenosine-methyltransferase METTL16

Ligandability

Cysteine 518 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 548 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA N6-adenosine-methyltransferase METTL16 between cysteines 181 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6gt5
Structure name
mettl16 mtase domain (crystal form 2)
Structure deposition date
2018-06-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q86W50
Residue number A
181
Residue number B
183
Peptide name
RNA N6-adenosine-methyltransferase METTL16

Ligandability

Cysteine 181 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RNA N6-adenosine-methyltransferase METTL16 between cysteines 181 and 247. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6b91
Structure name
crystal structure of the n-terminal domain of human mettl16
Structure deposition date
2017-10-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
75
Peptide accession
Q86W50
Residue number A
181
Residue number B
247
Peptide name
RNA N6-adenosine-methyltransferase METTL16

Ligandability

Cysteine 181 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 247 of RNA N6-adenosine-methyltransferase METTL16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: