ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chromodomain-helicase-DNA-binding protein 1-like

Intramolecular
Cysteine 63 and cysteine 67 L
Cysteine 102 and cysteine 123
A redox-regulated disulphide may form within Chromodomain-helicase-DNA-binding protein 1-like between cysteines 63 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7otq
Structure name
cryo-em structure of alc1/chd1l bound to a parylated nucleosome
Structure deposition date
2021-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
46
Peptide accession
Q86WJ1
Residue number A
63
Residue number B
67
Peptide name
Chromodomain-helicase-DNA-binding protein 1-like

Ligandability

Cysteine 63 of Chromodomain-helicase-DNA-binding protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Chromodomain-helicase-DNA-binding protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chromodomain-helicase-DNA-binding protein 1-like between cysteines 102 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7epu
Structure name
crystal structure of hsalc1
Structure deposition date
2021-04-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
96
Peptide accession
Q86WJ1
Residue number A
102
Residue number B
123
Peptide name
Chromodomain-helicase-DNA-binding protein 1-like

Ligandability

Cysteine 102 of Chromodomain-helicase-DNA-binding protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Chromodomain-helicase-DNA-binding protein 1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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