ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Stimulator of interferon genes protein

Intermolecular
Cysteine 148 and cysteine 148
Intramolecular
Cysteine 64 and cysteine 88 L
Cysteine 206 and cysteine 292
A redox-regulated disulphide may form between two units of Stimulator of interferon genes protein at cysteines 148 and 148.

Details

Redox score ?
75
PDB code
8gt6
Structure name
human sting with agonist hb3089
Structure deposition date
2022-09-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
7
% buried
57
Peptide A name
Stimulator of interferon genes protein
Peptide B name
Stimulator of interferon genes protein
Peptide A accession
Q86WV6
Peptide B accession
Q86WV6
Peptide A residue number
148
Peptide B residue number
148

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Stimulator of interferon genes protein between cysteines 64 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
8gt6
Structure name
human sting with agonist hb3089
Structure deposition date
2022-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
52
Peptide accession
Q86WV6
Residue number A
64
Residue number B
88
Peptide name
Stimulator of interferon genes protein

Ligandability

Cysteine 64 of Stimulator of interferon genes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Stimulator of interferon genes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Stimulator of interferon genes protein between cysteines 206 and 292. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
8a2h
Structure name
human sting in complex with 2',3'-cyclic-gmp-7-deazaphenyl-amp
Structure deposition date
2022-06-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
76
Peptide accession
Q86WV6
Residue number A
206
Residue number B
292
Peptide name
Stimulator of interferon genes protein

Ligandability

Cysteine 206 of Stimulator of interferon genes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Stimulator of interferon genes protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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