ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Intramolecular
Cysteine 257 and cysteine 258
Cysteine 240 and cysteine 251
A redox-regulated disulphide may form within 4-hydroxy-2-oxoglutarate aldolase, mitochondrial between cysteines 257 and 258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3s5o
Structure name
crystal structure of human 4-hydroxy-2-oxoglutarate aldolase bound to pyruvate
Structure deposition date
2011-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
36
Peptide accession
Q86XE5
Residue number A
257
Residue number B
258
Peptide name
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Ligandability

Cysteine 257 of 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 4-hydroxy-2-oxoglutarate aldolase, mitochondrial between cysteines 240 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
3s5n
Structure name
crystal structure of human 4-hydroxy-2-oxoglutarate aldolase
Structure deposition date
2011-05-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
82
Peptide accession
Q86XE5
Residue number A
240
Residue number B
251
Peptide name
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Ligandability

Cysteine 240 of 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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