ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

F-box only protein 11

Intermolecular
Cysteine 872 and cysteine 899
Cysteine 890 and cysteine 872
Cysteine 868 and cysteine 888
Cysteine 868 and cysteine 899
Cysteine 865 and cysteine 888
Cysteine 890 and cysteine 868
Cysteine 890 and cysteine 853
Cysteine 888 and cysteine 872
Cysteine 899 and cysteine 865
Cysteine 890 and cysteine 865
More...
Cysteine 856 and cysteine 890
Intramolecular
Cysteine 868 and cysteine 872
Cysteine 890 and cysteine 899
Cysteine 865 and cysteine 868
Cysteine 853 and cysteine 856
Cysteine 888 and cysteine 890
Cysteine 888 and cysteine 899
Cysteine 865 and cysteine 872
Cysteine 856 and cysteine 872
A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 872 and 899.

Details

Redox score ?
87
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
6
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
872
Peptide B residue number
899

Ligandability

Cysteine 872 of F-box only protein 11

Cysteine 899 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 890 and 872.

Details

Redox score ?
83
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
20
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
890
Peptide B residue number
872

Ligandability

Cysteine 890 of F-box only protein 11

Cysteine 872 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 868 and 888.

Details

Redox score ?
83
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
6
% buried
26
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
868
Peptide B residue number
888

Ligandability

Cysteine 868 of F-box only protein 11

Cysteine 888 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 868 and 899.

Details

Redox score ?
83
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
8
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
868
Peptide B residue number
899

Ligandability

Cysteine 868 of F-box only protein 11

Cysteine 899 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 865 and 888.

Details

Redox score ?
76
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
42
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
865
Peptide B residue number
888

Ligandability

Cysteine 865 of F-box only protein 11

Cysteine 888 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 890 and 868.

Details

Redox score ?
73
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
22
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
890
Peptide B residue number
868

Ligandability

Cysteine 890 of F-box only protein 11

Cysteine 868 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 890 and 853.

Details

Redox score ?
66
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
0
% buried
53
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
890
Peptide B residue number
853

Ligandability

Cysteine 890 of F-box only protein 11

Cysteine 853 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 888 and 872.

Details

Redox score ?
64
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
20
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
888
Peptide B residue number
872

Ligandability

Cysteine 888 of F-box only protein 11

Cysteine 872 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 899 and 865.

Details

Redox score ?
62
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
12
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
899
Peptide B residue number
865

Ligandability

Cysteine 899 of F-box only protein 11

Cysteine 865 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 890 and 865. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
26
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
890
Peptide B residue number
865

Ligandability

Cysteine 890 of F-box only protein 11

Cysteine 865 of F-box only protein 11

A redox-regulated disulphide may form between two units of F-box only protein 11 at cysteines 856 and 890. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
10
Peptide A name
F-box only protein 11
Peptide B name
F-box only protein 11
Peptide A accession
Q86XK2
Peptide B accession
Q86XK2
Peptide A residue number
856
Peptide B residue number
890

Ligandability

Cysteine 856 of F-box only protein 11

Cysteine 890 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 868 and 872.

Details

Redox score ?
83
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
8
Peptide accession
Q86XK2
Residue number A
868
Residue number B
872
Peptide name
F-box only protein 11

Ligandability

Cysteine 868 of F-box only protein 11

Cysteine 872 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 890 and 899.

Details

Redox score ?
83
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
6
Peptide accession
Q86XK2
Residue number A
890
Residue number B
899
Peptide name
F-box only protein 11

Ligandability

Cysteine 890 of F-box only protein 11

Cysteine 899 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 865 and 868.

Details

Redox score ?
77
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
18
Peptide accession
Q86XK2
Residue number A
865
Residue number B
868
Peptide name
F-box only protein 11

Ligandability

Cysteine 865 of F-box only protein 11

Cysteine 868 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 853 and 856.

Details

Redox score ?
76
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
33
Peptide accession
Q86XK2
Residue number A
853
Residue number B
856
Peptide name
F-box only protein 11

Ligandability

Cysteine 853 of F-box only protein 11

Cysteine 856 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 888 and 890.

Details

Redox score ?
75
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
27
Peptide accession
Q86XK2
Residue number A
888
Residue number B
890
Peptide name
F-box only protein 11

Ligandability

Cysteine 888 of F-box only protein 11

Cysteine 890 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 888 and 899.

Details

Redox score ?
71
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
20
Peptide accession
Q86XK2
Residue number A
888
Residue number B
899
Peptide name
F-box only protein 11

Ligandability

Cysteine 888 of F-box only protein 11

Cysteine 899 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 865 and 872.

Details

Redox score ?
60
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
6
% buried
18
Peptide accession
Q86XK2
Residue number A
865
Residue number B
872
Peptide name
F-box only protein 11

Ligandability

Cysteine 865 of F-box only protein 11

Cysteine 872 of F-box only protein 11

A redox-regulated disulphide may form within F-box only protein 11 between cysteines 856 and 872. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5vmd
Structure name
crystal structure of ubr-box from ubr6 in a domain-swapping conformation
Structure deposition date
2017-04-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
5
Peptide accession
Q86XK2
Residue number A
856
Residue number B
872
Peptide name
F-box only protein 11

Ligandability

Cysteine 856 of F-box only protein 11

Cysteine 872 of F-box only protein 11

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