ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cation channel sperm-associated auxiliary subunit delta

Intermolecular
Cysteine 384 and cysteine 680 of Cation channel sperm-associated auxiliary subunit epsilon
Intramolecular
Cysteine 621 and cysteine 651
Cysteine 20 and cysteine 366
Cysteine 56 and cysteine 143
Cysteine 142 and cysteine 149
Cysteine 522 and cysteine 569
Cysteine 384 and cysteine 493
Cysteine 507 and cysteine 701
Cysteine 142 and cysteine 143
Cysteine 143 and cysteine 149
More...
Cysteine 56 and cysteine 142
Cysteine 56 and cysteine 149
A redox-regulated disulphide may form between cysteine 384 of Cation channel sperm-associated auxiliary subunit delta and cysteine 680 of Cation channel sperm-associated auxiliary subunit epsilon. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide A name
Cation channel sperm-associated auxiliary subunit delta
Peptide B name
Cation channel sperm-associated auxiliary subunit epsilon
Peptide A accession
E9Q9F6
Peptide B accession
P0DP43
Peptide A residue number
384
Peptide B residue number
680

Ligandability

Cysteine 384 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 680 of Cation channel sperm-associated auxiliary subunit epsilon

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 621 and 651.

Details

Redox score ?
88
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
621
Residue number B
651
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 621 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 651 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 20 and 366.

Details

Redox score ?
84
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
20
Residue number B
366
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 20 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 366 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 56 and 143.

Details

Redox score ?
84
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
56
Residue number B
143
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 56 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 143 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 142 and 149.

Details

Redox score ?
83
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
142
Residue number B
149
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 142 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 149 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 522 and 569.

Details

Redox score ?
83
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
522
Residue number B
569
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 522 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 569 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 384 and 493.

Details

Redox score ?
81
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
384
Residue number B
493
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 384 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 493 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 507 and 701.

Details

Redox score ?
81
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
507
Residue number B
701
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 507 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 701 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 142 and 143. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
142
Residue number B
143
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 142 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 143 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 143 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
143
Residue number B
149
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 143 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 149 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 56 and 142. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
56
Residue number B
142
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 56 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 142 of Cation channel sperm-associated auxiliary subunit delta

A redox-regulated disulphide may form within Cation channel sperm-associated auxiliary subunit delta between cysteines 56 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7eeb
Structure name
structure of the catspermasome
Structure deposition date
2021-03-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
E9Q9F6
Residue number A
56
Residue number B
149
Peptide name
Cation channel sperm-associated auxiliary subunit delta

Ligandability

Cysteine 56 of Cation channel sperm-associated auxiliary subunit delta

Cysteine 149 of Cation channel sperm-associated auxiliary subunit delta

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