ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytosolic phospholipase A2 delta

Intramolecular
Cysteine 163 and cysteine 274
Cysteine 690 and cysteine 721
A redox-regulated disulphide may form within Cytosolic phospholipase A2 delta between cysteines 163 and 274.

Details

Redox score ?
81
PDB code
5iz5
Structure name
human givd cytosolic phospholipase a2
Structure deposition date
2016-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
56
Peptide accession
Q86XP0
Residue number A
163
Residue number B
274
Peptide name
Cytosolic phospholipase A2 delta

Ligandability

Cysteine 163 of Cytosolic phospholipase A2 delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of Cytosolic phospholipase A2 delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytosolic phospholipase A2 delta between cysteines 690 and 721. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5izr
Structure name
human givd cytosolic phospholipase a2 in complex with methyl gamma- linolenyl fluorophosphonate inhibitor and terbium chloride
Structure deposition date
2016-03-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86XP0
Residue number A
690
Residue number B
721
Peptide name
Cytosolic phospholipase A2 delta

Ligandability

Cysteine 690 of Cytosolic phospholipase A2 delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 721 of Cytosolic phospholipase A2 delta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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