ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-dependent RNA helicase DDX42

Intramolecular
Cysteine 333 and cysteine 339
Cysteine 339 and cysteine 382
Cysteine 333 and cysteine 382
Cysteine 333 and cysteine 346
A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX42 between cysteines 333 and 339.

Details

Redox score ?
69
PDB code
8dpe
Structure name
crystal structure of atp-dependent rna helicase ddx42
Structure deposition date
2022-07-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
90
Peptide accession
Q86XP3
Residue number A
333
Residue number B
339
Peptide name
ATP-dependent RNA helicase DDX42

Ligandability

Cysteine 333 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX42 between cysteines 339 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
8dpe
Structure name
crystal structure of atp-dependent rna helicase ddx42
Structure deposition date
2022-07-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
90
Peptide accession
Q86XP3
Residue number A
339
Residue number B
382
Peptide name
ATP-dependent RNA helicase DDX42

Ligandability

Cysteine 339 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX42 between cysteines 333 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
8dpe
Structure name
crystal structure of atp-dependent rna helicase ddx42
Structure deposition date
2022-07-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
14
% buried
100
Peptide accession
Q86XP3
Residue number A
333
Residue number B
382
Peptide name
ATP-dependent RNA helicase DDX42

Ligandability

Cysteine 333 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase DDX42 between cysteines 333 and 346. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
8dpe
Structure name
crystal structure of atp-dependent rna helicase ddx42
Structure deposition date
2022-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
13
% buried
100
Peptide accession
Q86XP3
Residue number A
333
Residue number B
346
Peptide name
ATP-dependent RNA helicase DDX42

Ligandability

Cysteine 333 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of ATP-dependent RNA helicase DDX42

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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