ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CDC42BPB protein

Intermolecular
Cysteine 36 and cysteine 41
Cysteine 41 and cysteine 41
Intramolecular
Cysteine 120 and cysteine 222
Cysteine 222 and cysteine 262
A redox-regulated disulphide may form between two units of CDC42BPB protein at cysteines 36 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3qfv
Structure name
mrck beta in complex with tpca-1
Structure deposition date
2011-01-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
84
Peptide A name
CDC42BPB protein
Peptide B name
CDC42BPB protein
Peptide A accession
Q86XZ8
Peptide B accession
Q86XZ8
Peptide A residue number
36
Peptide B residue number
41

Ligandability

Cysteine 36 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of CDC42BPB protein at cysteines 41 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3qfv
Structure name
mrck beta in complex with tpca-1
Structure deposition date
2011-01-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
66
Peptide A name
CDC42BPB protein
Peptide B name
CDC42BPB protein
Peptide A accession
Q86XZ8
Peptide B accession
Q86XZ8
Peptide A residue number
41
Peptide B residue number
41

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CDC42BPB protein between cysteines 120 and 222. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3qfv
Structure name
mrck beta in complex with tpca-1
Structure deposition date
2011-01-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
89
Peptide accession
Q86XZ8
Residue number A
120
Residue number B
222
Peptide name
CDC42BPB protein

Ligandability

Cysteine 120 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CDC42BPB protein between cysteines 222 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
3qfv
Structure name
mrck beta in complex with tpca-1
Structure deposition date
2011-01-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
14
% buried
100
Peptide accession
Q86XZ8
Residue number A
222
Residue number B
262
Peptide name
CDC42BPB protein

Ligandability

Cysteine 222 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of CDC42BPB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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