ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Xylosyltransferase 1

Intramolecular
Cysteine 301 and cysteine 542
Cysteine 675 and cysteine 927
Cysteine 257 and cysteine 285
Cysteine 561 and cysteine 574
Cysteine 563 and cysteine 572
Cysteine 920 and cysteine 933
Cysteine 276 and cysteine 471
Cysteine 563 and cysteine 574
Cysteine 572 and cysteine 574
Cysteine 561 and cysteine 563
Cysteine 561 and cysteine 572
A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 301 and 542.

Details

Redox score ?
88
PDB code
6ejc
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsgvgqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
301
Residue number B
542
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 301 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 542 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 675 and 927.

Details

Redox score ?
85
PDB code
6ejd
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsggpqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
675
Residue number B
927
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 675 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 927 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 257 and 285.

Details

Redox score ?
84
PDB code
6ejb
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsaggqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
257
Residue number B
285
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 257 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 561 and 574.

Details

Redox score ?
83
PDB code
6ejd
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsggpqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
561
Residue number B
574
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 561 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 563 and 572.

Details

Redox score ?
82
PDB code
6ejc
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsgvgqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
563
Residue number B
572
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 563 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 920 and 933.

Details

Redox score ?
81
PDB code
6ejc
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsgvgqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
920
Residue number B
933
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 920 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 933 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 276 and 471.

Details

Redox score ?
77
PDB code
6ejc
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsgvgqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
20
Peptide accession
Q86Y38
Residue number A
276
Residue number B
471
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 276 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 563 and 574. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6ejb
Structure name
human xylosyltransferase 1 in complex with peptide qeeegsaggqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
563
Residue number B
574
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 563 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 572 and 574. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6foa
Structure name
human xylosyltransferase 1 apo structure
Structure deposition date
2018-02-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
572
Residue number B
574
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 572 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 561 and 563. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6eja
Structure name
human xylosyltransferase 1 in complex with peptide qeeeysgggqgg
Structure deposition date
2017-09-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
561
Residue number B
563
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 561 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 563 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xylosyltransferase 1 between cysteines 561 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6foa
Structure name
human xylosyltransferase 1 apo structure
Structure deposition date
2018-02-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86Y38
Residue number A
561
Residue number B
572
Peptide name
Xylosyltransferase 1

Ligandability

Cysteine 561 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 572 of Xylosyltransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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