ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Partner and localizer of BRCA2

Intramolecular
Cysteine 868 and cysteine 891
A redox-regulated disulphide may form within Partner and localizer of BRCA2 between cysteines 868 and 891. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3eu7
Structure name
crystal structure of a palb2 / brca2 complex
Structure deposition date
2008-10-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
36
Peptide accession
Q86YC2
Residue number A
868
Residue number B
891
Peptide name
Partner and localizer of BRCA2

Ligandability

Cysteine 868 of Partner and localizer of BRCA2

Cysteine 891 of Partner and localizer of BRCA2

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