ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Defensin-like peptide 1

Intramolecular
Cysteine 48 and cysteine 64 L
Cysteine 40 and cysteine 56
Cysteine 33 and cysteine 63 L
Cysteine 33 and cysteine 40
Cysteine 40 and cysteine 63 L
Cysteine 63 and cysteine 64 L
Cysteine 33 and cysteine 48
Cysteine 40 and cysteine 48
A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 48 and 64 (24 and 40 respectively in this structure).

Details

Redox score ?
87
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
48
Residue number B
64
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 48 of Defensin-like peptide 1

Cysteine 64 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 40 and 56 (16 and 32 respectively in this structure).

Details

Redox score ?
85
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
40
Residue number B
56
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 40 of Defensin-like peptide 1

Cysteine 56 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 33 and 63 (9 and 39 respectively in this structure).

Details

Redox score ?
84
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
33
Residue number B
63
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 33 of Defensin-like peptide 1

Cysteine 63 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 33 and 40 (9 and 16 respectively in this structure).

Details

Redox score ?
69
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
33
Residue number B
40
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 33 of Defensin-like peptide 1

Cysteine 40 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 40 and 63 (16 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
40
Residue number B
63
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 40 of Defensin-like peptide 1

Cysteine 63 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 63 and 64 (39 and 40 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
63
Residue number B
64
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 63 of Defensin-like peptide 1

Cysteine 64 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 33 and 48 (9 and 24 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
33
Residue number B
48
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 33 of Defensin-like peptide 1

Cysteine 48 of Defensin-like peptide 1

A redox-regulated disulphide may form within Defensin-like peptide 1 between cysteines 40 and 48 (16 and 24 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
1b8w
Structure name
defensin-like peptide 1
Structure deposition date
1999-02-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P82172
Residue number A
40
Residue number B
48
Peptide name
Defensin-like peptide 1

Ligandability

Cysteine 40 of Defensin-like peptide 1

Cysteine 48 of Defensin-like peptide 1

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