E3 ubiquitin-protein ligase MIB1
Intermolecular
Cysteine 286 and cysteine 286
Intramolecular
Cysteine 85 and cysteine 88 L
Cysteine 100 and cysteine 103
Cysteine 88 and cysteine 112 L
Cysteine 85 and cysteine 109
Cysteine 88 and cysteine 109 L
Cysteine 109 and cysteine 112
Cysteine 85 and cysteine 112
4tse A 286 B 286
A redox-regulated disulphide may form between two units of E3 ubiquitin-protein ligase MIB1 at cysteines 286 and 286. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4tse
Structure name
crystal structure of the mib repeat domain of mind bomb 1
Structure deposition date
2014-06-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
94
Peptide A name
E3 ubiquitin-protein ligase MIB1
Peptide B name
E3 ubiquitin-protein ligase MIB1
Peptide A accession
Q86YT6
Peptide B accession
Q86YT6
Peptide A residue number
286
Peptide B residue number
286
Ligandability
4xi7 A 85 A 88
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 85 and 88.
Details
Redox score ?
83
PDB code
4xi7
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with jagged1 n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
5
% buried
nan
Peptide accession
Q86YT6
Residue number A
85
Residue number B
88
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 85 of E3 ubiquitin-protein ligase MIB1
Cysteine 88 of E3 ubiquitin-protein ligase MIB1
4xi7 A 100 A 103
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 100 and 103.
Details
Redox score ?
80
PDB code
4xi7
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with jagged1 n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
20
Peptide accession
Q86YT6
Residue number A
100
Residue number B
103
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 100 of E3 ubiquitin-protein ligase MIB1
Cysteine 103 of E3 ubiquitin-protein ligase MIB1
4xi7 A 88 A 112
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 88 and 112.
Details
Redox score ?
78
PDB code
4xi7
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with jagged1 n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
5
% buried
74
Peptide accession
Q86YT6
Residue number A
88
Residue number B
112
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 88 of E3 ubiquitin-protein ligase MIB1
Cysteine 112 of E3 ubiquitin-protein ligase MIB1
4xib A 85 A 109
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 85 and 109.
Details
Redox score ?
60
PDB code
4xib
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with fly delta n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
14
% buried
nan
Peptide accession
Q86YT6
Residue number A
85
Residue number B
109
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 85 of E3 ubiquitin-protein ligase MIB1
Cysteine 109 of E3 ubiquitin-protein ligase MIB1
4xi6 A 88 A 109
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 88 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
4xi6
Structure name
crystal structure of the mzm-rep domains of mind bomb 1
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
15
% buried
nan
Peptide accession
Q86YT6
Residue number A
88
Residue number B
109
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 88 of E3 ubiquitin-protein ligase MIB1
Cysteine 109 of E3 ubiquitin-protein ligase MIB1
4xi7 A 109 A 112
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 109 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
4xi7
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with jagged1 n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
14
% buried
91
Peptide accession
Q86YT6
Residue number A
109
Residue number B
112
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 109 of E3 ubiquitin-protein ligase MIB1
Cysteine 112 of E3 ubiquitin-protein ligase MIB1
4xib A 85 A 112
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase MIB1 between cysteines 85 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4xib
Structure name
crystal structure of the mzm-rep domains of mind bomb 1 in complex with fly delta n-box peptide
Structure deposition date
2015-01-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
23
% buried
nan
Peptide accession
Q86YT6
Residue number A
85
Residue number B
112
Peptide name
E3 ubiquitin-protein ligase MIB1
Ligandability
Cysteine 85 of E3 ubiquitin-protein ligase MIB1
Cysteine 112 of E3 ubiquitin-protein ligase MIB1
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