ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Junctional adhesion molecule-like

Intramolecular
Cysteine 158 and cysteine 236
Cysteine 45 and cysteine 119
A redox-regulated disulphide may form within Junctional adhesion molecule-like between cysteines 158 and 236 (138 and 216 respectively in this structure).

Details

Redox score ?
81
PDB code
3mj9
Structure name
crystal structure of jaml in complex with the stimulatory antibody hl4e10
Structure deposition date
2010-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80UL9
Residue number A
158
Residue number B
236
Peptide name
Junctional adhesion molecule-like

Ligandability

Cysteine 158 of Junctional adhesion molecule-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Junctional adhesion molecule-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Junctional adhesion molecule-like between cysteines 45 and 119 (25 and 99 respectively in this structure).

Details

Redox score ?
81
PDB code
3mj9
Structure name
crystal structure of jaml in complex with the stimulatory antibody hl4e10
Structure deposition date
2010-04-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80UL9
Residue number A
45
Residue number B
119
Peptide name
Junctional adhesion molecule-like

Ligandability

Cysteine 45 of Junctional adhesion molecule-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of Junctional adhesion molecule-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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