ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Trem-like transcript 1 protein

Intramolecular
Cysteine 52 and cysteine 59
Cysteine 38 and cysteine 104
Cysteine 52 and cysteine 104
Cysteine 59 and cysteine 104
Cysteine 38 and cysteine 52
A redox-regulated disulphide may form within Trem-like transcript 1 protein between cysteines 52 and 59.

Details

Redox score ?
86
PDB code
2frg
Structure name
structure of the immunoglobulin-like domain of human tlt-1
Structure deposition date
2006-01-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86YW5
Residue number A
52
Residue number B
59
Peptide name
Trem-like transcript 1 protein

Ligandability

Cysteine 52 of Trem-like transcript 1 protein

Cysteine 59 of Trem-like transcript 1 protein

A redox-regulated disulphide may form within Trem-like transcript 1 protein between cysteines 38 and 104.

Details

Redox score ?
81
PDB code
2frg
Structure name
structure of the immunoglobulin-like domain of human tlt-1
Structure deposition date
2006-01-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86YW5
Residue number A
38
Residue number B
104
Peptide name
Trem-like transcript 1 protein

Ligandability

Cysteine 38 of Trem-like transcript 1 protein

Cysteine 104 of Trem-like transcript 1 protein

A redox-regulated disulphide may form within Trem-like transcript 1 protein between cysteines 52 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2frg
Structure name
structure of the immunoglobulin-like domain of human tlt-1
Structure deposition date
2006-01-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86YW5
Residue number A
52
Residue number B
104
Peptide name
Trem-like transcript 1 protein

Ligandability

Cysteine 52 of Trem-like transcript 1 protein

Cysteine 104 of Trem-like transcript 1 protein

A redox-regulated disulphide may form within Trem-like transcript 1 protein between cysteines 59 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2frg
Structure name
structure of the immunoglobulin-like domain of human tlt-1
Structure deposition date
2006-01-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86YW5
Residue number A
59
Residue number B
104
Peptide name
Trem-like transcript 1 protein

Ligandability

Cysteine 59 of Trem-like transcript 1 protein

Cysteine 104 of Trem-like transcript 1 protein

A redox-regulated disulphide may form within Trem-like transcript 1 protein between cysteines 38 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2frg
Structure name
structure of the immunoglobulin-like domain of human tlt-1
Structure deposition date
2006-01-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q86YW5
Residue number A
38
Residue number B
52
Peptide name
Trem-like transcript 1 protein

Ligandability

Cysteine 38 of Trem-like transcript 1 protein

Cysteine 52 of Trem-like transcript 1 protein

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