a tool for identifying drug-targetable redox-active disulphides

Interferon lambda-1

Intramolecular

Cysteine 68 and cysteine 164

A redox-regulated disulphide may form within Interferon lambda-1 between cysteines 68 and 164 (49 and 145 respectively in this structure).

Details

Redox score ?

85

PDB code

Structure name

the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212

Structure deposition date

2010-08-16

Thiol separation (Å)

2

Half-sphere exposure sum ?

56

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

68

Residue number B

164

Peptide name

Interferon lambda-1

Ligandability

Cysteine 68 of Interferon lambda-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Interferon lambda-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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