ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon lambda receptor 1

Intramolecular
Cysteine 74 and cysteine 82
Cysteine 86 and cysteine 150
Cysteine 195 and cysteine 217
A redox-regulated disulphide may form within Interferon lambda receptor 1 between cysteines 74 and 82 (54 and 62 respectively in this structure).

Details

Redox score ?
86
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IU57
Residue number A
74
Residue number B
82
Peptide name
Interferon lambda receptor 1

Ligandability

Cysteine 74 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 82 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda receptor 1 between cysteines 86 and 150 (66 and 130 respectively in this structure).

Details

Redox score ?
85
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IU57
Residue number A
86
Residue number B
150
Peptide name
Interferon lambda receptor 1

Ligandability

Cysteine 86 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon lambda receptor 1 between cysteines 195 and 217 (175 and 197 respectively in this structure).

Details

Redox score ?
84
PDB code
5t5w
Structure name
structure of an affinity matured lambda-ifn/ifn-lambdar1/il-10rbeta receptor complex
Structure deposition date
2016-08-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IU57
Residue number A
195
Residue number B
217
Peptide name
Interferon lambda receptor 1

Ligandability

Cysteine 195 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Interferon lambda receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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