a tool for identifying drug-targetable redox-active disulphides

Calcium/calmodulin-dependent protein kinase type 1D

Intramolecular

Cysteine 204 and cysteine 270 L

A redox-regulated disulphide may form within Calcium/calmodulin-dependent protein kinase type 1D between cysteines 204 and 270.

Details

Redox score ?

73

PDB code

Structure name

crystal structure of human calmodulin-dependent protein kinase 1d (camk1d) in complex with fz326

Structure deposition date

2022-10-26

Thiol separation (Å)

3

Half-sphere exposure sum ?

86

Minimum pK_a ?

8

% buried

92

Peptide accession

Residue number A

204

Residue number B

270

Peptide name

Calcium/calmodulin-dependent protein kinase type 1D

Ligandability

Cysteine 204 of Calcium/calmodulin-dependent protein kinase type 1D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Calcium/calmodulin-dependent protein kinase type 1D

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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