ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TIR domain-containing adapter molecule 1

Intramolecular
Cysteine 428 and cysteine 441
Cysteine 109 and cysteine 144
A redox-regulated disulphide may form within TIR domain-containing adapter molecule 1 between cysteines 428 and 441. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2m1x
Structure name
ticam-1 tir domain structure
Structure deposition date
2012-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
28
Peptide accession
Q8IUC6
Residue number A
428
Residue number B
441
Peptide name
TIR domain-containing adapter molecule 1

Ligandability

Cysteine 428 of TIR domain-containing adapter molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of TIR domain-containing adapter molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TIR domain-containing adapter molecule 1 between cysteines 109 and 144. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2m63
Structure name
the protease-resistant n-terminal domain of tir-domain containing adaptor molecule-1, ticam-1
Structure deposition date
2013-03-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
38
Peptide accession
Q8IUC6
Residue number A
109
Residue number B
144
Peptide name
TIR domain-containing adapter molecule 1

Ligandability

Cysteine 109 of TIR domain-containing adapter molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of TIR domain-containing adapter molecule 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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