ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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E3 ubiquitin-protein ligase RNF135

Intramolecular
Cysteine 347 and cysteine 402
Cysteine 347 and cysteine 348
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF135 between cysteines 347 and 402.

Details

Redox score ?
71
PDB code
7jl1
Structure name
cryo-em structure of rig-i:dsrna in complex with riplet pryspry domain (monomer)
Structure deposition date
2020-07-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
61
Peptide accession
Q8IUD6
Residue number A
347
Residue number B
402
Peptide name
E3 ubiquitin-protein ligase RNF135

Ligandability

Cysteine 347 of E3 ubiquitin-protein ligase RNF135

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 402 of E3 ubiquitin-protein ligase RNF135

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF135 between cysteines 347 and 348. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7jl3
Structure name
cryo-em structure of rig-i:dsrna filament in complex with riplet pryspry domain (trimer)
Structure deposition date
2020-07-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
83
Peptide accession
Q8IUD6
Residue number A
347
Residue number B
348
Peptide name
E3 ubiquitin-protein ligase RNF135

Ligandability

Cysteine 347 of E3 ubiquitin-protein ligase RNF135

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 348 of E3 ubiquitin-protein ligase RNF135

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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