a tool for identifying drug-targetable redox-active disulphides

Ribosomal oxygenase 2

Intramolecular

Cysteine 103 and cysteine 105

A redox-regulated disulphide may form within Ribosomal oxygenase 2 between cysteines 103 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

42

PDB code

Structure name

60s ribosomal protein l27a histidine hydroxylase (mina53 y209c) in complex with mn(ii), 2-oxoglutarate (2og) and 60s ribosomal protein l27a (rpl27a g37c) peptide fragment

Structure deposition date

2013-07-10

Thiol separation (Å)

9

Half-sphere exposure sum ?

64

Minimum pK_a ?

10

% buried

62

Peptide accession

Residue number A

103

Residue number B

105

Peptide name

Ribosomal oxygenase 2

Ligandability

Cysteine 103 of Ribosomal oxygenase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Ribosomal oxygenase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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