ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytokine receptor-like factor 3

Intramolecular
Cysteine 313 and cysteine 423
Cysteine 336 and cysteine 353
A redox-regulated disulphide may form within Cytokine receptor-like factor 3 between cysteines 313 and 423 (140 and 250 respectively in this structure).

Details

Redox score ?
74
PDB code
6rpz
Structure name
cytokine receptor-like factor 3 c-terminus residues 174-442: native collected with 1
Structure deposition date
2019-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
52
Peptide accession
Q9Z2L7
Residue number A
313
Residue number B
423
Peptide name
Cytokine receptor-like factor 3

Ligandability

Cysteine 313 of Cytokine receptor-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 423 of Cytokine receptor-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor-like factor 3 between cysteines 336 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6rpy
Structure name
cytokine receptor-like factor 3 c-terminus residues 174-442: hg-sad derivative
Structure deposition date
2019-05-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
5
% buried
93
Peptide accession
Q9Z2L7
Residue number A
336
Residue number B
353
Peptide name
Cytokine receptor-like factor 3

Ligandability

Cysteine 336 of Cytokine receptor-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Cytokine receptor-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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