ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuronal PAS domain-containing protein 4

Intramolecular
Cysteine 149 and cysteine 192
A redox-regulated disulphide may form within Neuronal PAS domain-containing protein 4 between cysteines 149 and 192 (149 and 193 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7xhv
Structure name
crystal structure of the npas4-arnt heterodimer in complex with dna
Structure deposition date
2022-04-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
13
% buried
92
Peptide accession
Q8BGD7
Residue number A
149
Residue number B
192
Peptide name
Neuronal PAS domain-containing protein 4

Ligandability

Cysteine 149 of Neuronal PAS domain-containing protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Neuronal PAS domain-containing protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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