ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-type lectin domain family 10 member A

Intramolecular
Cysteine 181 and cysteine 192
Cysteine 209 and cysteine 304
Cysteine 282 and cysteine 296
A redox-regulated disulphide may form within C-type lectin domain family 10 member A between cysteines 181 and 192.

Details

Redox score ?
86
PDB code
6w12
Structure name
crystal structure of the carbohydrate recognition domain of the human macrophage galactose c-type lectin bound to the tumor-associated tn antigen
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IUN9
Residue number A
181
Residue number B
192
Peptide name
C-type lectin domain family 10 member A

Ligandability

Cysteine 181 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 10 member A between cysteines 209 and 304 (31 and 126 respectively in this structure).

Details

Redox score ?
81
PDB code
6puv
Structure name
crystal structure of the carbohydrate recognition domain of the human macrophage galactose c-type lectin
Structure deposition date
2019-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IUN9
Residue number A
209
Residue number B
304
Peptide name
C-type lectin domain family 10 member A

Ligandability

Cysteine 209 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 10 member A between cysteines 282 and 296.

Details

Redox score ?
81
PDB code
6w12
Structure name
crystal structure of the carbohydrate recognition domain of the human macrophage galactose c-type lectin bound to the tumor-associated tn antigen
Structure deposition date
2020-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IUN9
Residue number A
282
Residue number B
296
Peptide name
C-type lectin domain family 10 member A

Ligandability

Cysteine 282 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of C-type lectin domain family 10 member A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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