Armadillo repeat-containing protein 8
Intramolecular
Cysteine 168 and cysteine 211
Cysteine 175 and cysteine 211
Cysteine 125 and cysteine 128
Cysteine 264 and cysteine 275
Cysteine 174 and cysteine 175
Cysteine 83 and cysteine 125
7nsc E 154 E 197
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 168 and 211 (154 and 197 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
98
Peptide accession
Q8IUR7
Residue number A
168
Residue number B
211
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 168 of Armadillo repeat-containing protein 8
Cysteine 211 of Armadillo repeat-containing protein 8
7nsc E 161 E 197
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 175 and 211 (161 and 197 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
82
Peptide accession
Q8IUR7
Residue number A
175
Residue number B
211
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 175 of Armadillo repeat-containing protein 8
Cysteine 211 of Armadillo repeat-containing protein 8
7nsc E 111 E 114
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 125 and 128 (111 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
82
Peptide accession
Q8IUR7
Residue number A
125
Residue number B
128
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 125 of Armadillo repeat-containing protein 8
Cysteine 128 of Armadillo repeat-containing protein 8
7nsc E 250 E 261
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 264 and 275 (250 and 261 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
57
Peptide accession
Q8IUR7
Residue number A
264
Residue number B
275
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 264 of Armadillo repeat-containing protein 8
Cysteine 275 of Armadillo repeat-containing protein 8
7nsc E 160 E 161
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 174 and 175 (160 and 161 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
64
Peptide accession
Q8IUR7
Residue number A
174
Residue number B
175
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 174 of Armadillo repeat-containing protein 8
Cysteine 175 of Armadillo repeat-containing protein 8
7nsc E 69 E 111
A redox-regulated disulphide may form within Armadillo repeat-containing protein 8 between cysteines 83 and 125 (69 and 111 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7nsc
Structure name
substrate receptor scaffolding module of human ctlh e3 ubiquitin ligase
Structure deposition date
2021-03-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
50
Peptide accession
Q8IUR7
Residue number A
83
Residue number B
125
Peptide name
Armadillo repeat-containing protein 8
Ligandability
Cysteine 83 of Armadillo repeat-containing protein 8
Cysteine 125 of Armadillo repeat-containing protein 8
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