ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Intramolecular
Cysteine 114 and cysteine 130
Cysteine 68 and cysteine 77
Cysteine 83 and cysteine 110
Cysteine 65 and cysteine 83
Cysteine 131 and cysteine 136
Cysteine 83 and cysteine 89
Cysteine 65 and cysteine 110
Cysteine 65 and cysteine 89
Cysteine 89 and cysteine 136
Cysteine 89 and cysteine 131
More...
Cysteine 65 and cysteine 136
Cysteine 65 and cysteine 131
Cysteine 65 and cysteine 77
Cysteine 114 and cysteine 131
Cysteine 65 and cysteine 114
Cysteine 83 and cysteine 136
Cysteine 130 and cysteine 131
Cysteine 89 and cysteine 114
Cysteine 89 and cysteine 110
Cysteine 83 and cysteine 131
Cysteine 114 and cysteine 136
Cysteine 110 and cysteine 131
Cysteine 89 and cysteine 130
Cysteine 130 and cysteine 136
Cysteine 110 and cysteine 136
A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 114 and 130.

Details

Redox score ?
86
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
114
Residue number B
130
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 114 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 130 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 68 and 77.

Details

Redox score ?
86
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
68
Residue number B
77
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 68 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 77 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 83 and 110.

Details

Redox score ?
85
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
83
Residue number B
110
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 83 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 110 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 83.

Details

Redox score ?
82
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
83
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 83 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 131 and 136.

Details

Redox score ?
80
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
131
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 83 and 89.

Details

Redox score ?
74
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
83
Residue number B
89
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 83 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 110.

Details

Redox score ?
72
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
110
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 110 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 89.

Details

Redox score ?
67
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
89
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 89 and 136.

Details

Redox score ?
67
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
89
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 89 and 131.

Details

Redox score ?
64
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
89
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 136.

Details

Redox score ?
61
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
77
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 77 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 114 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
114
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 114 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 65 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
65
Residue number B
114
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 65 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 114 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 83 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
83
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 83 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 130 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6oau
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in gnti-deficient hek293-f cells
Structure deposition date
2019-03-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
130
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 130 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 89 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
89
Residue number B
114
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 114 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 89 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6e7k
Structure name
structure of the lipoprotein lipase gpihbp1 complex that mediates plasma triglyceride hydrolysis
Structure deposition date
2018-07-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
89
Residue number B
110
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 110 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 83 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
83
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 83 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 114 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
114
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 114 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 110 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
110
Residue number B
131
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 110 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 131 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 89 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6oau
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in gnti-deficient hek293-f cells
Structure deposition date
2019-03-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
89
Residue number B
130
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 89 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 130 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 130 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6ob0
Structure name
compound 2 bound structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
130
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 130 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

A redox-regulated disulphide may form within Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 between cysteines 110 and 136. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6oaz
Structure name
apo structure of wt lipoprotein lipase in complex with gpihbp1 mutant n78d n82d produced in hek293-f cells
Structure deposition date
2019-03-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IV16
Residue number A
110
Residue number B
136
Peptide name
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Ligandability

Cysteine 110 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Cysteine 136 of Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

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