a tool for identifying drug-targetable redox-active disulphides

3'-5' exoribonuclease 1

Intramolecular

Cysteine 139 and cysteine 186

A redox-regulated disulphide may form within 3'-5' exoribonuclease 1 between cysteines 139 and 186.

Details

Redox score ?

77

PDB code

Structure name

crystallographic structure of the nuclease domain of 3'hexo, a deddh family member, bound to ramp

Structure deposition date

2004-06-04

Thiol separation (Å)

4

Half-sphere exposure sum ?

61

Minimum pK_a ?

7

% buried

62

Peptide accession

Residue number A

139

Residue number B

186

Peptide name

3'-5' exoribonuclease 1

Ligandability

Cysteine 139 of 3'-5' exoribonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of 3'-5' exoribonuclease 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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