ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho guanine nucleotide exchange factor TIAM2

Intermolecular
Cysteine 592 and cysteine 564
Intramolecular
Cysteine 543 and cysteine 617
Cysteine 592 and cysteine 738
Cysteine 617 and cysteine 694
A redox-regulated disulphide may form between two units of Rho guanine nucleotide exchange factor TIAM2 at cysteines 592 and 564. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
3a8p
Structure name
crystal structure of the tiam2 phccex domain
Structure deposition date
2009-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
81
Peptide A name
Rho guanine nucleotide exchange factor TIAM2
Peptide B name
Rho guanine nucleotide exchange factor TIAM2
Peptide A accession
Q6ZPF3
Peptide B accession
Q6ZPF3
Peptide A residue number
592
Peptide B residue number
564

Ligandability

Cysteine 592 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor TIAM2 between cysteines 543 and 617.

Details

Redox score ?
71
PDB code
3a8p
Structure name
crystal structure of the tiam2 phccex domain
Structure deposition date
2009-10-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
8
% buried
83
Peptide accession
Q6ZPF3
Residue number A
543
Residue number B
617
Peptide name
Rho guanine nucleotide exchange factor TIAM2

Ligandability

Cysteine 543 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 617 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor TIAM2 between cysteines 592 and 738. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3a8p
Structure name
crystal structure of the tiam2 phccex domain
Structure deposition date
2009-10-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
76
Peptide accession
Q6ZPF3
Residue number A
592
Residue number B
738
Peptide name
Rho guanine nucleotide exchange factor TIAM2

Ligandability

Cysteine 592 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 738 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor TIAM2 between cysteines 617 and 694. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3a8p
Structure name
crystal structure of the tiam2 phccex domain
Structure deposition date
2009-10-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
100
Peptide accession
Q6ZPF3
Residue number A
617
Residue number B
694
Peptide name
Rho guanine nucleotide exchange factor TIAM2

Ligandability

Cysteine 617 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 694 of Rho guanine nucleotide exchange factor TIAM2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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