a tool for identifying drug-targetable redox-active disulphides

Mitofusin-1

Intramolecular

Cysteine 111 and cysteine 156

A redox-regulated disulphide may form within Mitofusin-1 between cysteines 111 and 156.

Details

Redox score ?

74

PDB code

Structure name

truncated mitofusin-1, nucleotide-free

Structure deposition date

2016-07-26

Thiol separation (Å)

3

Half-sphere exposure sum ?

64

Minimum pK_a ?

10

% buried

42

Peptide accession

Residue number A

111

Residue number B

156

Peptide name

Mitofusin-1

Ligandability

Cysteine 111 of Mitofusin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Mitofusin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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