ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DCN1-like protein 3

Intramolecular
Cysteine 119 and cysteine 163
Cysteine 115 and cysteine 140 L
A redox-regulated disulphide may form within DCN1-like protein 3 between cysteines 119 and 163. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
4gba
Structure name
dcnl complex with n-terminally acetylated nedd8 e2 peptide
Structure deposition date
2012-07-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
9
% buried
11
Peptide accession
Q8IWE4
Residue number A
119
Residue number B
163
Peptide name
DCN1-like protein 3

Ligandability

Cysteine 119 of DCN1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of DCN1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DCN1-like protein 3 between cysteines 115 and 140. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4gba
Structure name
dcnl complex with n-terminally acetylated nedd8 e2 peptide
Structure deposition date
2012-07-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
72
Peptide accession
Q8IWE4
Residue number A
115
Residue number B
140
Peptide name
DCN1-like protein 3

Ligandability

Cysteine 115 of DCN1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of DCN1-like protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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