ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Iron-sulfur cluster co-chaperone protein HscB

Intramolecular
Cysteine 41 and cysteine 44
Cysteine 41 and cysteine 58
Cysteine 41 and cysteine 61
Cysteine 44 and cysteine 61
Cysteine 58 and cysteine 61
Cysteine 44 and cysteine 58
A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 41 and 44.

Details

Redox score ?
83
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
7
% buried
30
Peptide accession
Q8IWL3
Residue number A
41
Residue number B
44
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 41 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 44 of Iron-sulfur cluster co-chaperone protein HscB

A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 41 and 58.

Details

Redox score ?
80
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
43
Peptide accession
Q8IWL3
Residue number A
41
Residue number B
58
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 41 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 58 of Iron-sulfur cluster co-chaperone protein HscB

A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 41 and 61.

Details

Redox score ?
79
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
7
% buried
40
Peptide accession
Q8IWL3
Residue number A
41
Residue number B
61
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 41 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 61 of Iron-sulfur cluster co-chaperone protein HscB

A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 44 and 61.

Details

Redox score ?
79
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
43
Peptide accession
Q8IWL3
Residue number A
44
Residue number B
61
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 44 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 61 of Iron-sulfur cluster co-chaperone protein HscB

A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 58 and 61.

Details

Redox score ?
76
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
54
Peptide accession
Q8IWL3
Residue number A
58
Residue number B
61
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 58 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 61 of Iron-sulfur cluster co-chaperone protein HscB

A redox-regulated disulphide may form within Iron-sulfur cluster co-chaperone protein HscB between cysteines 44 and 58.

Details

Redox score ?
72
PDB code
3bvo
Structure name
crystal structure of human co-chaperone protein hscb
Structure deposition date
2008-01-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
11
% buried
44
Peptide accession
Q8IWL3
Residue number A
44
Residue number B
58
Peptide name
Iron-sulfur cluster co-chaperone protein HscB

Ligandability

Cysteine 44 of Iron-sulfur cluster co-chaperone protein HscB

Cysteine 58 of Iron-sulfur cluster co-chaperone protein HscB

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