ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sodium channel subunit beta-4

Intermolecular
Cysteine 58 and cysteine 58
Cysteine 58 and cysteine 919 of Sodium channel protein type 1 subunit alpha
Cysteine 58 and cysteine 921 of Sodium channel protein type 1 subunit alpha
Intramolecular
Cysteine 53 and cysteine 131
A redox-regulated disulphide may form between two units of Sodium channel subunit beta-4 at cysteines 58 and 58.

Details

Redox score ?
86
PDB code
5xaw
Structure name
parallel homodimer structures of voltage-gated sodium channel beta4 for cell-cell adhesion
Structure deposition date
2017-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-4
Peptide B name
Sodium channel subunit beta-4
Peptide A accession
Q8IWT1
Peptide B accession
Q8IWT1
Peptide A residue number
58
Peptide B residue number
58

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 58 of Sodium channel subunit beta-4 and cysteine 919 of Sodium channel protein type 1 subunit alpha.

Details

Redox score ?
85
PDB code
7dtd
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-4
Peptide B name
Sodium channel protein type 1 subunit alpha
Peptide A accession
Q8IWT1
Peptide B accession
P35498
Peptide A residue number
58
Peptide B residue number
919

Ligandability

Cysteine 58 of Sodium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 919 of Sodium channel protein type 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 58 of Sodium channel subunit beta-4 and cysteine 921 of Sodium channel protein type 1 subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7dtd
Structure name
voltage-gated sodium channel nav1
Structure deposition date
2021-01-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-4
Peptide B name
Sodium channel protein type 1 subunit alpha
Peptide A accession
Q8IWT1
Peptide B accession
P35498
Peptide A residue number
58
Peptide B residue number
921

Ligandability

Cysteine 58 of Sodium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 921 of Sodium channel protein type 1 subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sodium channel subunit beta-4 between cysteines 53 and 131.

Details

Redox score ?
70
PDB code
5xaw
Structure name
parallel homodimer structures of voltage-gated sodium channel beta4 for cell-cell adhesion
Structure deposition date
2017-03-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
98
Peptide accession
Q8IWT1
Residue number A
53
Residue number B
131
Peptide name
Sodium channel subunit beta-4

Ligandability

Cysteine 53 of Sodium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Sodium channel subunit beta-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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