ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Volume-regulated anion channel subunit LRRC8A

Intramolecular
Cysteine 57 and cysteine 65
Cysteine 113 and cysteine 295
Cysteine 54 and cysteine 310
Cysteine 295 and cysteine 310
Cysteine 113 and cysteine 310
Cysteine 54 and cysteine 113
Cysteine 54 and cysteine 295
Cysteine 65 and cysteine 295
Cysteine 65 and cysteine 310
Cysteine 57 and cysteine 310
More...
Cysteine 139 and cysteine 336
Cysteine 57 and cysteine 295
Cysteine 65 and cysteine 113
Cysteine 54 and cysteine 65
Cysteine 57 and cysteine 113
Cysteine 54 and cysteine 57
A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 57 and 65.

Details

Redox score ?
86
PDB code
6djb
Structure name
structure of human volume regulated anion channel composed of swell1 (lrrc8a)
Structure deposition date
2018-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IWT6
Residue number A
57
Residue number B
65
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 57 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 113 and 295.

Details

Redox score ?
86
PDB code
6djb
Structure name
structure of human volume regulated anion channel composed of swell1 (lrrc8a)
Structure deposition date
2018-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IWT6
Residue number A
113
Residue number B
295
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 113 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 54 and 310.

Details

Redox score ?
80
PDB code
6djb
Structure name
structure of human volume regulated anion channel composed of swell1 (lrrc8a)
Structure deposition date
2018-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IWT6
Residue number A
54
Residue number B
310
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 295 and 310.

Details

Redox score ?
74
PDB code
7p5y
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb3
Structure deposition date
2021-07-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
295
Residue number B
310
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 295 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 113 and 310.

Details

Redox score ?
74
PDB code
7p5v
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb1
Structure deposition date
2021-07-15
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
113
Residue number B
310
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 113 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 54 and 113.

Details

Redox score ?
72
PDB code
6djb
Structure name
structure of human volume regulated anion channel composed of swell1 (lrrc8a)
Structure deposition date
2018-05-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IWT6
Residue number A
54
Residue number B
113
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 54 and 295.

Details

Redox score ?
70
PDB code
7p5w
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb2
Structure deposition date
2021-07-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
54
Residue number B
295
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 65 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7p5v
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb1
Structure deposition date
2021-07-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
65
Residue number B
295
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 65 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 65 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6nzz
Structure name
lrrc8a-dcpib in msp1e3d1 nanodisc expanded state
Structure deposition date
2019-02-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
65
Residue number B
310
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 65 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 57 and 310. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7m19
Structure name
sn-407-lrrc8a in msp1e3d1 lipid nanodiscs (pose-2)
Structure deposition date
2021-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
57
Residue number B
310
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 57 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 139 and 336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7p60
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb4 at 1:0
Structure deposition date
2021-07-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
80
Peptide accession
Q80WG5
Residue number A
139
Residue number B
336
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 139 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 57 and 295. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6djb
Structure name
structure of human volume regulated anion channel composed of swell1 (lrrc8a)
Structure deposition date
2018-05-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IWT6
Residue number A
57
Residue number B
295
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 57 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 65 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7p5w
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb2
Structure deposition date
2021-07-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
65
Residue number B
113
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 65 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 54 and 65. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7p5v
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb1
Structure deposition date
2021-07-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
54
Residue number B
65
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 65 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 57 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7p5y
Structure name
structure of homomeric lrrc8a volume-regulated anion channel in complex with synthetic nanobody sb3
Structure deposition date
2021-07-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
57
Residue number B
113
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 57 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Volume-regulated anion channel subunit LRRC8A between cysteines 54 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
8b42
Structure name
structure of heteromeric lrrc8a/c volume-regulated anion channel
Structure deposition date
2022-09-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q80WG5
Residue number A
54
Residue number B
57
Peptide name
Volume-regulated anion channel subunit LRRC8A

Ligandability

Cysteine 54 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Volume-regulated anion channel subunit LRRC8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: