ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proton-coupled zinc antiporter SLC30A8

Intramolecular
Cysteine 361 and cysteine 364
A redox-regulated disulphide may form within Proton-coupled zinc antiporter SLC30A8 between cysteines 361 and 364.

Details

Redox score ?
85
PDB code
6xpe
Structure name
cryo-em structure of human znt8 wt, in the presence of zinc, determined in outward-facing conformation
Structure deposition date
2020-07-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
10
Peptide accession
Q8IWU4
Residue number A
361
Residue number B
364
Peptide name
Proton-coupled zinc antiporter SLC30A8

Ligandability

Cysteine 361 of Proton-coupled zinc antiporter SLC30A8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Proton-coupled zinc antiporter SLC30A8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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