ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Contactin-4

Intramolecular
Cysteine 144 and cysteine 194
Cysteine 50 and cysteine 100
Cysteine 337 and cysteine 384
Cysteine 247 and cysteine 295
A redox-regulated disulphide may form within Contactin-4 between cysteines 144 and 194.

Details

Redox score ?
83
PDB code
3kld
Structure name
ptprg cntn4 complex
Structure deposition date
2009-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14BL8
Residue number A
144
Residue number B
194
Peptide name
Contactin-4

Ligandability

Cysteine 144 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-4 between cysteines 50 and 100.

Details

Redox score ?
82
PDB code
3jxa
Structure name
immunoglobulin domains 1-4 of mouse cntn4
Structure deposition date
2009-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14BL8
Residue number A
50
Residue number B
100
Peptide name
Contactin-4

Ligandability

Cysteine 50 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-4 between cysteines 337 and 384.

Details

Redox score ?
81
PDB code
3kld
Structure name
ptprg cntn4 complex
Structure deposition date
2009-11-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14BL8
Residue number A
337
Residue number B
384
Peptide name
Contactin-4

Ligandability

Cysteine 337 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 384 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Contactin-4 between cysteines 247 and 295.

Details

Redox score ?
81
PDB code
3jxa
Structure name
immunoglobulin domains 1-4 of mouse cntn4
Structure deposition date
2009-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q14BL8
Residue number A
247
Residue number B
295
Peptide name
Contactin-4

Ligandability

Cysteine 247 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Contactin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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