ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein KIBRA

Intermolecular
Cysteine 771 and cysteine 771
Intramolecular
Cysteine 705 and cysteine 711
Cysteine 749 and cysteine 759
A redox-regulated disulphide may form between two units of Protein KIBRA at cysteines 771 and 771.

Details

Redox score ?
82
PDB code
6fd0
Structure name
human kibra c2 domain mutant m734i s735a
Structure deposition date
2017-12-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein KIBRA
Peptide B name
Protein KIBRA
Peptide A accession
Q8IX03
Peptide B accession
Q8IX03
Peptide A residue number
771
Peptide B residue number
771

Ligandability

A redox-regulated disulphide may form within Protein KIBRA between cysteines 705 and 711.

Details

Redox score ?
86
PDB code
6fjd
Structure name
human kibra c2 domain mutant c771a in complex with phosphatidylinositol 4,5-bisphosphate
Structure deposition date
2018-01-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IX03
Residue number A
705
Residue number B
711
Peptide name
Protein KIBRA

Ligandability

Cysteine 705 of Protein KIBRA

Cysteine 711 of Protein KIBRA

A redox-regulated disulphide may form within Protein KIBRA between cysteines 749 and 759.

Details

Redox score ?
82
PDB code
6fjd
Structure name
human kibra c2 domain mutant c771a in complex with phosphatidylinositol 4,5-bisphosphate
Structure deposition date
2018-01-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IX03
Residue number A
749
Residue number B
759
Peptide name
Protein KIBRA

Ligandability

Cysteine 749 of Protein KIBRA

Cysteine 759 of Protein KIBRA

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