ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CD302 antigen

Intramolecular
Cysteine 24 and cysteine 36
Cysteine 128 and cysteine 143
Cysteine 56 and cysteine 153
A redox-regulated disulphide may form within CD302 antigen between cysteines 24 and 36.

Details

Redox score ?
84
PDB code
2nan
Structure name
nmr structure of human dcl-1 (cd302) extracellular domain
Structure deposition date
2016-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IX05
Residue number A
24
Residue number B
36
Peptide name
CD302 antigen

Ligandability

Cysteine 24 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD302 antigen between cysteines 128 and 143.

Details

Redox score ?
83
PDB code
2nan
Structure name
nmr structure of human dcl-1 (cd302) extracellular domain
Structure deposition date
2016-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IX05
Residue number A
128
Residue number B
143
Peptide name
CD302 antigen

Ligandability

Cysteine 128 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD302 antigen between cysteines 56 and 153.

Details

Redox score ?
81
PDB code
2nan
Structure name
nmr structure of human dcl-1 (cd302) extracellular domain
Structure deposition date
2016-01-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IX05
Residue number A
56
Residue number B
153
Peptide name
CD302 antigen

Ligandability

Cysteine 56 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of CD302 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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