ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Neuronal PAS domain-containing protein 3

Intramolecular
Cysteine 351 and cysteine 371
A redox-regulated disulphide may form within Neuronal PAS domain-containing protein 3 between cysteines 351 and 371. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5sy7
Structure name
crystal structure of the heterodimeric npas3-arnt complex with hre dna
Structure deposition date
2016-08-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
78
Peptide accession
Q9QZQ0
Residue number A
351
Residue number B
371
Peptide name
Neuronal PAS domain-containing protein 3

Ligandability

Cysteine 351 of Neuronal PAS domain-containing protein 3

Cysteine 371 of Neuronal PAS domain-containing protein 3

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