ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonucleoprotein PTB-binding 1

Intramolecular
Cysteine 239 and cysteine 251 L
Cysteine 224 and cysteine 297
Cysteine 222 and cysteine 297
Cysteine 222 and cysteine 224
Cysteine 135 and cysteine 297
A redox-regulated disulphide may form within Ribonucleoprotein PTB-binding 1 between cysteines 239 and 251.

Details

Redox score ?
85
PDB code
3h2u
Structure name
human raver1 rrm1, rrm2, and rrm3 domains in complex with human vinculin tail domain vt
Structure deposition date
2009-04-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IY67
Residue number A
239
Residue number B
251
Peptide name
Ribonucleoprotein PTB-binding 1

Ligandability

Cysteine 239 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleoprotein PTB-binding 1 between cysteines 224 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
3vf0
Structure name
raver1 in complex with metavinculin l954 deletion mutant
Structure deposition date
2012-01-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
92
Minimum pKa ?
8
% buried
100
Peptide accession
Q8IY67
Residue number A
224
Residue number B
297
Peptide name
Ribonucleoprotein PTB-binding 1

Ligandability

Cysteine 224 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleoprotein PTB-binding 1 between cysteines 222 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3vf0
Structure name
raver1 in complex with metavinculin l954 deletion mutant
Structure deposition date
2012-01-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
89
Peptide accession
Q8IY67
Residue number A
222
Residue number B
297
Peptide name
Ribonucleoprotein PTB-binding 1

Ligandability

Cysteine 222 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleoprotein PTB-binding 1 between cysteines 222 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3h2u
Structure name
human raver1 rrm1, rrm2, and rrm3 domains in complex with human vinculin tail domain vt
Structure deposition date
2009-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
86
Peptide accession
Q8IY67
Residue number A
222
Residue number B
224
Peptide name
Ribonucleoprotein PTB-binding 1

Ligandability

Cysteine 222 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonucleoprotein PTB-binding 1 between cysteines 135 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
3h2u
Structure name
human raver1 rrm1, rrm2, and rrm3 domains in complex with human vinculin tail domain vt
Structure deposition date
2009-04-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q8IY67
Residue number A
135
Residue number B
297
Peptide name
Ribonucleoprotein PTB-binding 1

Ligandability

Cysteine 135 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Ribonucleoprotein PTB-binding 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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