ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Nucleotidyltransferase MB21D2

Intramolecular
Cysteine 368 and cysteine 374
Cysteine 144 and cysteine 382
Cysteine 164 and cysteine 165
Cysteine 374 and cysteine 382
Cysteine 301 and cysteine 340
A redox-regulated disulphide may form within Nucleotidyltransferase MB21D2 between cysteines 368 and 374.

Details

Redox score ?
80
PDB code
7lt1
Structure name
structure of the cgas-like receptor human mb21d2
Structure deposition date
2021-02-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
7
% buried
81
Peptide accession
Q8IYB1
Residue number A
368
Residue number B
374
Peptide name
Nucleotidyltransferase MB21D2

Ligandability

Cysteine 368 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 374 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nucleotidyltransferase MB21D2 between cysteines 144 and 382.

Details

Redox score ?
71
PDB code
7lt1
Structure name
structure of the cgas-like receptor human mb21d2
Structure deposition date
2021-02-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
89
Peptide accession
Q8IYB1
Residue number A
144
Residue number B
382
Peptide name
Nucleotidyltransferase MB21D2

Ligandability

Cysteine 144 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nucleotidyltransferase MB21D2 between cysteines 164 and 165. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7lt1
Structure name
structure of the cgas-like receptor human mb21d2
Structure deposition date
2021-02-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
72
Peptide accession
Q8IYB1
Residue number A
164
Residue number B
165
Peptide name
Nucleotidyltransferase MB21D2

Ligandability

Cysteine 164 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nucleotidyltransferase MB21D2 between cysteines 374 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7lt1
Structure name
structure of the cgas-like receptor human mb21d2
Structure deposition date
2021-02-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
86
Peptide accession
Q8IYB1
Residue number A
374
Residue number B
382
Peptide name
Nucleotidyltransferase MB21D2

Ligandability

Cysteine 374 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nucleotidyltransferase MB21D2 between cysteines 301 and 340. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7lt1
Structure name
structure of the cgas-like receptor human mb21d2
Structure deposition date
2021-02-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
54
Peptide accession
Q8IYB1
Residue number A
301
Residue number B
340
Peptide name
Nucleotidyltransferase MB21D2

Ligandability

Cysteine 301 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Nucleotidyltransferase MB21D2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: