ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DIS3-like exonuclease 2

Intramolecular
Cysteine 376 and cysteine 487
Cysteine 283 and cysteine 301
Cysteine 447 and cysteine 451
Cysteine 376 and cysteine 394
A redox-regulated disulphide may form within DIS3-like exonuclease 2 between cysteines 376 and 487.

Details

Redox score ?
68
PDB code
4pmw
Structure name
structure of mouse dis3l2 in complex with oligou rna substrate
Structure deposition date
2014-05-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
70
Peptide accession
Q8CI75
Residue number A
376
Residue number B
487
Peptide name
DIS3-like exonuclease 2

Ligandability

Cysteine 376 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 487 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DIS3-like exonuclease 2 between cysteines 283 and 301. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4pmw
Structure name
structure of mouse dis3l2 in complex with oligou rna substrate
Structure deposition date
2014-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
56
Peptide accession
Q8CI75
Residue number A
283
Residue number B
301
Peptide name
DIS3-like exonuclease 2

Ligandability

Cysteine 283 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DIS3-like exonuclease 2 between cysteines 447 and 451. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4pmw
Structure name
structure of mouse dis3l2 in complex with oligou rna substrate
Structure deposition date
2014-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
100
Peptide accession
Q8CI75
Residue number A
447
Residue number B
451
Peptide name
DIS3-like exonuclease 2

Ligandability

Cysteine 447 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 451 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DIS3-like exonuclease 2 between cysteines 376 and 394. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
4pmw
Structure name
structure of mouse dis3l2 in complex with oligou rna substrate
Structure deposition date
2014-05-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
77
Peptide accession
Q8CI75
Residue number A
376
Residue number B
394
Peptide name
DIS3-like exonuclease 2

Ligandability

Cysteine 376 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of DIS3-like exonuclease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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