ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

ATP-dependent RNA helicase SUPV3L1, mitochondrial

Intramolecular
Cysteine 230 and cysteine 279
Cysteine 274 and cysteine 279
Cysteine 230 and cysteine 274
Cysteine 279 and cysteine 313
Cysteine 251 and cysteine 274
Cysteine 369 and cysteine 372
A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 230 and 279.

Details

Redox score ?
68
PDB code
7w1r
Structure name
crystal structure of human suv3 monomer
Structure deposition date
2021-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
100
Peptide accession
Q8IYB8
Residue number A
230
Residue number B
279
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 230 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 274 and 279.

Details

Redox score ?
63
PDB code
3rc3
Structure name
human mitochondrial helicase suv3
Structure deposition date
2011-03-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
100
Peptide accession
Q8IYB8
Residue number A
274
Residue number B
279
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 274 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 230 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7w1r
Structure name
crystal structure of human suv3 monomer
Structure deposition date
2021-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
89
Minimum pKa ?
10
% buried
100
Peptide accession
Q8IYB8
Residue number A
230
Residue number B
274
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 230 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 279 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3rc3
Structure name
human mitochondrial helicase suv3
Structure deposition date
2011-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
64
Peptide accession
Q8IYB8
Residue number A
279
Residue number B
313
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 279 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 251 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3rc8
Structure name
human mitochondrial helicase suv3 in complex with short rna fragment
Structure deposition date
2011-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
86
Peptide accession
Q8IYB8
Residue number A
251
Residue number B
274
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 251 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 274 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent RNA helicase SUPV3L1, mitochondrial between cysteines 369 and 372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
3rc8
Structure name
human mitochondrial helicase suv3 in complex with short rna fragment
Structure deposition date
2011-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
Q8IYB8
Residue number A
369
Residue number B
372
Peptide name
ATP-dependent RNA helicase SUPV3L1, mitochondrial

Ligandability

Cysteine 369 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 372 of ATP-dependent RNA helicase SUPV3L1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: