ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fanconi anemia group M protein

Intramolecular
Cysteine 1819 and cysteine 1848
Cysteine 1848 and cysteine 1853
A redox-regulated disulphide may form within Fanconi anemia group M protein between cysteines 1819 and 1848. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4m6w
Structure name
crystal structure of the c-terminal segment of fancm in complex with faap24
Structure deposition date
2013-08-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
56
Peptide accession
Q8IYD8
Residue number A
1819
Residue number B
1848
Peptide name
Fanconi anemia group M protein

Ligandability

Cysteine 1819 of Fanconi anemia group M protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1848 of Fanconi anemia group M protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia group M protein between cysteines 1848 and 1853. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4m6w
Structure name
crystal structure of the c-terminal segment of fancm in complex with faap24
Structure deposition date
2013-08-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
66
Peptide accession
Q8IYD8
Residue number A
1848
Residue number B
1853
Peptide name
Fanconi anemia group M protein

Ligandability

Cysteine 1848 of Fanconi anemia group M protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1853 of Fanconi anemia group M protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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