ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Osteoclast-associated immunoglobulin-like receptor

Intramolecular
Cysteine 53 and cysteine 100
Cysteine 150 and cysteine 195
Cysteine 100 and cysteine 101
Cysteine 53 and cysteine 101
A redox-regulated disulphide may form within Osteoclast-associated immunoglobulin-like receptor between cysteines 53 and 100 (28 and 75 respectively in this structure).

Details

Redox score ?
81
PDB code
5eiv
Structure name
crystal structure of complex of osteoclast-associated immunoglobulin- like receptor (oscar) and a synthetic collagen consensus peptide
Structure deposition date
2015-10-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYS5
Residue number A
53
Residue number B
100
Peptide name
Osteoclast-associated immunoglobulin-like receptor

Ligandability

Cysteine 53 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Osteoclast-associated immunoglobulin-like receptor between cysteines 150 and 195 (125 and 170 respectively in this structure).

Details

Redox score ?
80
PDB code
5eiv
Structure name
crystal structure of complex of osteoclast-associated immunoglobulin- like receptor (oscar) and a synthetic collagen consensus peptide
Structure deposition date
2015-10-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYS5
Residue number A
150
Residue number B
195
Peptide name
Osteoclast-associated immunoglobulin-like receptor

Ligandability

Cysteine 150 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Osteoclast-associated immunoglobulin-like receptor between cysteines 100 and 101 (75 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5eiq
Structure name
human oscar ligand-binding domain
Structure deposition date
2015-10-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IYS5
Residue number A
100
Residue number B
101
Peptide name
Osteoclast-associated immunoglobulin-like receptor

Ligandability

Cysteine 100 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Osteoclast-associated immunoglobulin-like receptor between cysteines 53 and 101 (57 and 105 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5cj8
Structure name
human osteoclast associated receptor (oscar) extracellular domain
Structure deposition date
2015-07-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8IYS5
Residue number A
53
Residue number B
101
Peptide name
Osteoclast-associated immunoglobulin-like receptor

Ligandability

Cysteine 53 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Osteoclast-associated immunoglobulin-like receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: