ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Izumo sperm-egg fusion protein 1

Intramolecular
Cysteine 139 and cysteine 165
Cysteine 135 and cysteine 159
Cysteine 25 and cysteine 152
Cysteine 182 and cysteine 233
Cysteine 22 and cysteine 149
Cysteine 22 and cysteine 25
Cysteine 25 and cysteine 149
Cysteine 22 and cysteine 152
Cysteine 149 and cysteine 152
Cysteine 165 and cysteine 182
More...
Cysteine 165 and cysteine 233
Cysteine 139 and cysteine 182
A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 139 and 165.

Details

Redox score ?
85
PDB code
5jk9
Structure name
crystal structure of human izumo1
Structure deposition date
2016-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
139
Residue number B
165
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 139 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 165 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 135 and 159.

Details

Redox score ?
85
PDB code
5f4t
Structure name
crystal structure of the human sperm izumo1 residues 22-254
Structure deposition date
2015-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
135
Residue number B
159
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 135 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 25 and 152.

Details

Redox score ?
85
PDB code
5jk9
Structure name
crystal structure of human izumo1
Structure deposition date
2016-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
25
Residue number B
152
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 25 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 182 and 233.

Details

Redox score ?
81
PDB code
5jkc
Structure name
crystal structure of human izumo1-juno complex (crystal form 1)
Structure deposition date
2016-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
182
Residue number B
233
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 182 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 22 and 149.

Details

Redox score ?
78
PDB code
5jkd
Structure name
crystal structure of human izumo1-juno complex (crystal form 2)
Structure deposition date
2016-04-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
22
Residue number B
149
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 22 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 22 and 25.

Details

Redox score ?
71
PDB code
5f4e
Structure name
crystal structure of the human sperm izumo1 and egg juno complex
Structure deposition date
2015-12-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
22
Residue number B
25
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 22 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 25 and 149.

Details

Redox score ?
60
PDB code
5jke
Structure name
crystal structure of human izumo1-juno complex (crystal form 3)
Structure deposition date
2016-04-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
25
Residue number B
149
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 25 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 22 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5jke
Structure name
crystal structure of human izumo1-juno complex (crystal form 3)
Structure deposition date
2016-04-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
22
Residue number B
152
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 22 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 149 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5f4v
Structure name
crystal structure of the human sperm izumo1 residues 22-268
Structure deposition date
2015-12-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
149
Residue number B
152
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 149 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 165 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5f4e
Structure name
crystal structure of the human sperm izumo1 and egg juno complex
Structure deposition date
2015-12-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
165
Residue number B
182
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 165 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 165 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5f4v
Structure name
crystal structure of the human sperm izumo1 residues 22-268
Structure deposition date
2015-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
165
Residue number B
233
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 165 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Izumo sperm-egg fusion protein 1 between cysteines 139 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5f4v
Structure name
crystal structure of the human sperm izumo1 residues 22-268
Structure deposition date
2015-12-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8IYV9
Residue number A
139
Residue number B
182
Peptide name
Izumo sperm-egg fusion protein 1

Ligandability

Cysteine 139 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Izumo sperm-egg fusion protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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